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Vitamin D deficiency has been proven to have a deleterious effect on bone remodeling and bone mineral density, by inducing secondary hyperparathyroidism. The lack of a present consensus on optimal serum 25 OH D levels required for the preservation of physiologic bone metabolism renders its follow-up difficult. The cross-sectional study was performed on a sample of 69 healthy men aged Statistical relationships between these parameters were calculated.

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The percentage of 25 OH D deficient or insufficient subjects was The results of the present study confirm the benefit in maintaining zanocin pentru prostatită normal bone turnover offered by serum 25 OH D in the upper normal range. The large percentage of patients with vitamin D insufficiency reinforce the necessity of a specific follow-up and of epidemiologic studies normal size prostate gland ml to our geographic area.

In a new legislation introduced the mandatory use of the iodized salt in a higher concentration in households of all 41 districts and also in the baking industry.

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The study aims to evaluate the effects of iodine legislation changes upon the urinary iodine excretion UIC in schoolchildren study group A and pregnant women study group B.

Urine samples were collected from schoolchildren aged years of 14 districts and from pregnant women of 11 districts in the years In two areas - Bistrita Nasaud and Bucharest - the number of schoolchildren was larger, i. UIC was determined in spot urine samples by Sandell Kolthoff? The results show in schoolchildren an increase of the median UIC in 9 out of 14 districts up to 90?

Six of these districts are in the Carpathian area. However, in pregnant women inUIC still showed low levels of 55?

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In conclusion, this study revealed an increase of median values of UIC in schoolchildren after universal salt iodization program. The persistence of iodine deficiency in pregnant women in the studied districts is an emergency problem that has to be solved as soon as possible. This fact involves the necessity of a large monitoring program in the next years, in all districts in urban and rural areas and in all known pockets of endemia.

Overall, 25 patients underwent additional radiotherapy, 13 in group A and 12 in group B. After radiotherapy, the medium prolactin level was 5. Among 23 patients resistant to initial DA treatment, only 8 patients were submitted to radiotherapy, 2 became responsive to DA thereafter and 2 others obtained a significant decrease of prolactin levels.

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The addition of radiotherapy is indicated for the cure of most prolactinomas. Bromocriptine treatment of pituitary adenomas. Evaluation of withdrawal effect. Normal size prostate gland ml Roumaine Med Endocrinol ; Molitch M. In: Melmed S, editor.

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The pituitary. Toronto, New York: Blackwell Publishing, Rapid changes of prolactinoma volume after withdrawal and reinstitution of bromocriptine. J Clin Endocrinol Metab ; 53 3 Long-term and lowdose treatment with cabergoline induces macroprolactinoma shrinkage.

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J Clin Endocrinol Metab ; 82 11 Tumor size changes in prolactinomas treated with minimum bromocriptine throughout gestation. Gynecological Endocrinology ; 14 suppl 2. TRH synthesis in?

Archive issue

J Cell Mol Med ; 5 1 Coculescu M. Neuroendocrinologie clinica. Bucuresti: Editura Stiintifica si Enciclopedica, Withdrawal of longterm cabergoline therapy for tumoral and nontumoral hyperprolactinemia.

N Engl J Med ; 21 Molitch ME. Dopamine resistance of prolactinomas.

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Pituitary ; 6 1 Medical management of prolactin-secreting pituitary adenomas. Pituitary ; 5 2 Resistance to cabergoline as compared with bromocriptine in hyperprolactinemia: prevalence, clinical definition, and therapeutic strategy.

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Surgical treatment of prolactin-secreting pituitary adenomas: early results and long-term outcome. J Clin Endocrinol Metab ; 87 7 A comparative evaluation of effectiveness of medical and surgical therapy in patients with macroprolactinoma. J Neurosurg Sci ; 45 2 Dopamine agonists and pituitary tumor shrinkage.

Dopamine agonists DA prevent tumor growth, but usually suppress prolactin PRL both in mother and fetus. Possible long-term consequences on fetal development remain unknown. Other 26 pregnancies in 21 patients were incompletely evaluated and included only in the pregnancy outcome and cure rate analysis. Treated patients were compared with the control group Y 8 women with PRM who discontinued DA after pregnancy induction 9 pregnancies and a control group Z of 46 healthy pregnant women, randomly selected from two departments of Obstetrics. Patients with multiple pregnancies were recorded in each corresponding study group.

Endocr Rev ; 13 2 Long-term follow-up of prolactinomas: normoprolactinemia after bromocriptine withdrawal. J Clin Endocrinol Metab ; 87 8 Radiological evidence for regression of prolactinoma after treatment with bromocriptine.

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Lancet ; 2 Reduction in size of a pituitary tumor by bromocriptine therapy. N Engl J Med ; 6 Rapid re-expansion of a macroprolactinoma after early discontinuation of bromocriptine. Pituitary ; 3 3 Necrotic changes in prolactinomas after long term administration of bromocriptine. J Clin Endocrinol Metab ; 59 3 Macroprolactinoma shrinkage during cabergoline treatment is greater in naive patients than in patients pretreated with other dopamine agonists: a prospective study in patie [CrossRef] Effects of the dopamine agonist cabergoline in patients with prolactinoma intolerant or resistant to bromocriptine.

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Eur J Endocrinol ; 4 A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group.

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N Engl J Med ; 14 Prolactinomas resistant to standard dopamine agonists respond to chronic cabergoline treatment. J Clin Endocrinol Metab ; 82 3 A luteinizing hormonealpha- subunit- and prolactin-secreting pituitary adenoma responsive to somatostatin analogs: in vivo and in vitro studies.

Eur J Endocrinol ; 1 Clinicopathologic study of cases of prolactin-secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas.

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Cancer ; 95 2 Multifunctional cells in human pituitary adenomas: implications for paradoxical secretion and tumorigenesis. J Clin Endocrinol Metab ; 89 9 Mignot M, Skinner DC. Cell Tissue Res ; 3 Resistance to bromocriptine in prolactinomas. J Clin Endocrinol Metab ; 69 3 Quantitative and functional expression of somatostatin receptor subtypes in human prolactinomas.

J Clin Endocrinol Metab ; 84 9 Alteration of G alpha subunits mRNA levels in bromocriptine resistant prolactinomas. J Neuroendocrinol ; 8 10 What is the final outcome in patients with macroprolactinoma resistant to dopamine agonists? K, Endocrine A.

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